A gas chamber is an apparatus for killing humans or animals with gas, consisting of a sealed chamber into which a poisonous or asphyxiant gas is introduced. The most commonly used poisonous agent is hydrogen cyanide; carbon dioxide and carbon monoxide have also been used. Gas chambers were used as a method of execution for condemned prisoners in the United States beginning in the 1920s. During the Holocaust, large-scale gas chambers designed for mass killing were used by Nazi Germany as part of their genocide program, and also by the Independent State of Croatia at the Jasenovac concentration camp. The use of gas chambers has also been reported in North Korea.