Cascioferro's life is full of myth and mystery. He became a legend even when he was alive, and that legend is partially responsible for creating the image of the gallant gentleman capomafia (Mafia boss). He is widely considered to have been the killer of New York City police officer Joe Petrosino, in charge of the Italian Squad, in 1909. However, he has never been convicted for the crime.
With the rise of Fascism in Italy his untouchable position declined. He was arrested and sentenced to death in 1930 and would remain in jail until his death. The exact year of his death remains unknown.